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- Sabine, Sabines, Sabin, Sabens, Saben
- Sackett, Sacket, Sackette
- Sadler, Saddler, Sandler, Sadlier
- Saffer, Saver, Safer
- Sailor, Sahler, Sailer, Sayler, Saylor, Seyler
- Saint John, St. John, Sainte John
- Salazar, Salasar
- Sale, Salle, Salles
- Salgado, Salty, Witty, Wry
- Salinas, Fortress, Building
- Salisbury, Sallsbury, Salsberry, Sansberry, Sandsbury
- Salley, Sally, Sallee, Sallie, Sallye, Saley
- Saltmarsh, Saltmarch, Saltmarked
- Samuels, Samuel, Samuells
- Sams, Sam, Samms, Sammes, Sames
- Sampson, Samson, Samsen
- Sanborn, Anburn, Sandborn
- Sanchez, Saunchez, Sandchez, Son of Sancho, Sanctius
- Sanders, Landers, Saunders
- Sanderson, Sandersen, Saunderson
- Sandoval, Sandivil, Sandovel
- Sands, Sand, Saund
- Sanford, Sanderford, Sandford, Saniford, Santford
- Sansum, Sansom, Sansume
- Santa, Maidens, Female Saint
- Santana, Follower of St. Anna
- Santiago, Saint, Saint of Tiago, Saint of Diego
- Santos, Saint, Family of Santo
- Sanz, Sanez, Sans
- Sargent, Sargeant, Seargent, Sergent, Sergeant
- Sarmento, Vine Trees, Tall and Thin
- Sater, Satter, Satar
- Satterthwaite, Satterthwait, Saterthwaite, Satterwhite
- Savage, Savege, Savige
- Sawyer, Sawyers, Sauyer, Sauyers
- Saye, Say, Sais, Sayes
- Sayles, Sayls, Sales
- Saylor, Sailor, Saylors, Sailors, Saylers, Sailer, Salor, Saler
- Scarborough, Scarbrough, Scarburgh
- Scates, Scales, Scals
- Schaarschmidt, Scharschmidt, Scharschmitt
- Scheetz, Scheets, Scheats
- Scheid, Schied, Scied
- Schell, Schel, Shell
- Schenck, Schenk, Schanck, Shcank, Scank
- Schermerhorn, Schermirhorn, Schermerhorne
- Schlayer, Schleier, Slyier, Slyer, Sloyer
- Schleppi, Schleppy, Schleappy
- Schmeisser, Smyser, Schmesser
- Schneider, Snyder, Snider, Shnider, Scheeder, Snader, Schnader, Schneder, Tailor
- Schneidman, Shneidman, Sneidman
- Scholl, Shull, Schole
- Schooler, Schuler, Schoolar, Schools
- Schoonover, Crumb, Schoonober
- Schott, Shott, Shutt
- Schreckengost, Schrecegost, Schrekegoste
- Schreier, Schrere, Shrier
- Schroeder, Tailor, Snyder
- Schropp, Schrob, Schrope, Shroup
- Schuck, Schauck, Schucks
- Schultz, Schulz, Schulze, Schults, Shultz, Shults
- Schwartz, Swartz, Swarts
- Schwartzwaller, Schwartzwaler, Schwartswaller
- Schweitzer, Switzer, Switser
- Schwenck, Schwenk. Schwencks
- Scio, Scios, Scioes
- Scobey, Scoby, Scobie, Scovy
- Scothorn, Scotthorn, Scothorne
- Scott, Scotte, Scotts
- Scotten, Scotton, Scottan
- Scovell, Scovil, Scoville
- Scribner, Scriber, Scripner
- Scrivener, Scrivenar, Scrivanar
- Scudder, Schudder, Schuder
- Seabourn, Seaborn, Seaburn
- Sealy, Sely, Seally, Sealie
- Seaman, Zeaman, Seman
- Searing, Zearing, Zerring, Zehring
- Searle, Searl, Searles, Cyrile, Cyrle, Cearl
- Searing, Zearing, Zehring
- Sears, Searz, Seares, Sayers, Sayre
- Sebring, Seabring
- Seebold, Silbaugh, Selbough
- Seeger, Sagare, Sager, Segar, Segor
- Seeley, Sealy, Seely, Seelye, Ceeley
- Sebastian, Bastian, Sabastian
- Sebree, Sebre, Seebre, Seabre
- Secrist, Seachrist, Seacrest, Secrest, Segrist
- Sedgwick, Sedwick, Sedgwicke
- Sedore, Sedor, Sedorre
- Seidel, Siedle, Sidle
- Seifert, Siefert, Safrit, Sifrid, Sifford, Seaford, Seford, Sifritt, Syfred, Cypert, Cyphert, Cyphret, Saphritz, Seiford, Sifret, Sifrett, Sifrid, Sifrid, Sifritt, Siphard
- Seguin, Segguin, Seguine
- Seitz, Sides, Sites, Sytz, Sights, Sites
- Self, Selfs, Selph
- Sell, Sel, Sells
- Sellers, Cellar, Seiler, Sellar, Sellars
- Selsor, Selzor, Sellsore, Seltzer, Selzer, Selser
- Seneca, Senecas
- Seney, Senie, Seany
- Senft, Senfte, Senpht
- Senter, Center, Sinter
- Sequeira, Arid Land
- Sereno, Calm, Serenity
- Serrano, Mountain Ridge, Group of Hills, Highlander
- Sessions, Sesson, Session
- Severance, Sufferance, Suffrance
- Seville, Sevill, Seaville
- Seward, Seaward, Sewards
- Sewell, Seawell, Sowell, Sewel, Showell
- Seybert, Seibert, Sibert, Siver, Sybert
- Seymour, Seymore, Seamore
- Shade, Schade, Shades, Shate, Shady
- Shah, King, Ruler
- Shaffer, Shafer, Schaefer, Schaeffer, Schafer, Schaffer, Shaeffer, Shaver, Shawver
- Shaffner, Shaffnir, Shafnir, Schaefer, Schaeffer, Schafer, Schaffer, Shaeffer, Shaver, Shawver
- Shallcross, Shallcros, Shalcross
- Shalle, Schally, Shally
- Shane, Shaine, Shain
- Shankland, Shanklan, Shanklin
- Shannon, Shannan, Shanon
- Sharp, Sharpp, Sharpe
- Shatswell, Shattswell, Shatwell
- Shattuck, Shaddack, Shaddock
- Shaul, Shall, Shawl
- Shaulus, Shallis, Shaullis, Shollas, Shules
- Shaver, Schaver, Shavor
- Shaw, Shaws, Shawe
- Shearer, Sherer, Scherer, Sherred, Shurer
- Shedaker, Shedacker, Shedakker
- Shee, She, Shea
- Sheetenhelm, Shittenhelm, Shitenhelm, Schit
- Sheffield, Sheffeld, Sheffeild
- Shekell, Shekel, Shekelle
- Shelby, Selby, Sealby, Celby
- Sheldon, Shelden, Shelldon, Shelton
- Shellenberger, Sollenberger, Solleberger, Shallenberger
- Shell, Shill, Sheall, Cheall
- Shelley, Shelly, Shely, Shellie
- Sheppard, Shepard, Shephard, Shepherd, Shiphard
- Sheppardson, Sheperdson, Sheperdsson, Sheppardson
- Sheraton, Sheradon, Sheriton, Shereton, Sherdon
- Sherman, Sherwin, Scheurman, Schirman, Schurman, Sharman, Shearman, Shermer, Shireman
- Sherrod, Sherard, Sherrad
- Sherwood, Sherwoode, Serwood
- Shetterly, Shetterley, Shetterely
- Shreve, Shearve
- Shilb, Shilbe, Shilve
- Shinn, Shin, Shinne, Chinn
- Shimer, Sheimer, Shemer
- Shields, Shield, Shielde
- Shinn, Shin, Shine
- Shindelbower, Shidelboer, Shindelbauer
- Shipe, Scheib, Shiep, Shipes
- Shipman, Shipmon, Shippman
- Shippley, Shipey, Shippee, Shipley
- Shirk, Scharch, Scherch, Scherich, Schorck, Shouck
- Shirts, Schertz, Shirtz, Shurtz
- Shittenhelm, Sheetenhelm, Shitenhelm, Schit
- Shive, Scheib, Shipe
- Shively, Shivelie, Shiveley
- Shivers, Shiver, Shever
- Shockley, Shockly, Shockleys
- Shoe, Shoue, Shaue
- Shoemaker, Shumaker, Schmacher, Schumacher, Shewmaker
- Sholes, Scholes, Shoales
- Shook, Schuck, Schook
- Shorb, Schrob, Schrop
- Short, Shorte, Shortt
- Shoup, Schaub, Shoop, Shope, Shoupe, Shupe, Shupp
- Showalter, Showater, Snowalter
- Shrader, Schrader, Shradar, Schreeder, Sheder
- Shropeshire, Shropesher, Sropesher, Shropsher, Sropser
- Shrum, Schramm, Srum
- Shuffler, Shufler, Shuflar
- Shurter, Sharter, Sherter, Shorter
- Shurtleff, Shurtiff, Shurtlif, Shurlif
- Sibley, Sibbley, Sibly
- Sickler, Sickels, Sickle
- Sides, Seitz, Seides
- Sidney, Sidneh, Sidnye
- Siegenthaler, Siegentaller, Sienthaler
- Siegfried, Sigfried, Siegfried
- Sievely, Sivley, Sivly
- Sigman, Sigeman, Siegman
- Sigwald, Sigwall, Sigwalt
- Silliman, Sillyman, Sillimen
- Silva, Poruguese for Woods or Forest
- Simms, Semmes, Sim, Sims, Symmes
- Simmons, Sammons, Seamans, Simmonds, Simonds, Simons, Symonds
- Simonton, Simanton, Simingten, Simington, Simison, Symenton
- Simpson, Sympson, Simson
- Sinclair, Cinclair, Clair, Clare, Sinclear, Sinkler, St.Clair
- Singer, Saenger, Sanger
- Singh, Lion, Like a Lion
- Singletary, Singletry, Singlety
- Singleton, Singleten, Singelton
- Sinquet, Sinket, Sincket
- Sischo, Sisco, Sysco
- Sisson, Sysson, Sissan
- Sitton, Siton, Sittin, Sittan
- Skeels, Skeeles, Skeals
- Skillman, Skilman, Skiliman
- Skinner, Skiner, Skinnier, Skinners
- Slack, Slak, Slacke
- Slade, Slad, Slades
- Slauson, Slason, Slasson, Slawson, Slossin
- Slaybach, Slaybaugh, Slayback, Slabach, Slebach
- Slayden, Slaton, Slaydon, Slayton
- Slusser, Schlosser, Slosser, Slusher
- Slyer, Schlayer, Scheier, Sloyer
- Sleeper, Slieper, Sleaper
- Slemmer, Schlemmer, Slimmer
- Slingerland, Singerland, Slingerlan
- Small, Smalley, Smeal, Schmell, Shmell
- Smallman, Smallmen, Smallan
- Smart, Smartt, Smarte
- Smedes, Smeds, Smides
- Smethurst, Smethursts, Smithurst
- Smiley, Smylie, Smilie
- Smith, Smyth, Smythe, Schmidt, Schmitt, Schmitz
- Smithfield, Smithfeld, Smithfeild
- Smithwick, Smithwitch, Smithwit, Smithwith
- Smoot, Schmutz, Smootz, Smutz
- Snable, Snabel, Snabal
- Snapp, Snapp, Snabb
- Snaveley, Snavely, Snevely, Snively
- Snead, Sneed, Sneid
- Sneddon, Snedon, Snedin
- Snell, Schnell, Schnelle
- Snelling, Snellings, Snellin
- Snodgrass, Snoddgrass, Snodgrasses
- Snow, Frost, Schnee
- Snowdon, Snowden, Snowdin, Snodon, Snotin
- Snuggs, Snugs, Snug
- Snyder, Schneder, Schneider, Schyder, Sneider, Snider, Shneider
- Solis, Soler, Town of Soler
- Sosa, Salsa Agua, Salt Water
- Soto, Near a Small Forest, Saltus
- Soule, Sol, Sole, Soul
- Souther, Souter, Sauther, South
- Southern, Sothoron, Southarn
- Southard, Southerd, Southward, Southworth, Suthard
- Southgate, Southgage, Southgaite
- Souto, By Grooves
- Sowers, Sower, Sauers, Sauer, Sours, Sour
- Spahr, Stoel, Stoell, Stowel
- Spain, DeSpain, Spaine, Spains
- Spangler, Spengler, Sprangller
- Spalding, Spaulding, Spaldings
- Spare, Speare, Speere
- Sparks, Spark, Sparcks
- Speakman, Spackman, Speckman
- Spealman, Speilman, Speelman
- Speare, Spear, Spears, Speer, Speers, Spier, Speir
- Specht, Speck, Spect
- Speake, Speak, Speakes
- Speed, Speeds, Speede
- Spelman, Spellman, Spillman, Spilman
- Spence, Spense, Speance
- Spencer, Spenser, Speancer, Spence
- Spenard, Spenart, Speanard
- Spickard, Spickert, Spickart, Spikart
- Spinola, Espinha, Spina
- Spittlehouse, Spittlehaus, Spitlehouse, Spittlehose, Spittlehowse
- Spohn, Spoon, Spoone
- Spooner, Spuner, Spunner
- Spring, Sprang, Sprieng, Springs
- Springer, Spranger, Sprangler, Sprinnger, Sprinner
- Sproul, Spraul, Sprawl
- Spruce, Spruse, Sprosh
- Spruill, Spruil, Spuil
- Squire, Squires, Squiers, Squier
- Staats, Stats, Stauts
- Stackhouse, Stackhose, Stockhouse
- Staderman, Strotherman, Strowderman
- Stagg, Stag, Stagge
- Stahl, Stahle, Stall, Steele
- Stahler, Staler, Stahlers, Staller
- Stalcup, Stalcap, Stalcape
- Stallard, Stalard, Stallards
- Stallings, Stalings, Stalling, Stailing, Stallion, Stallions
- Stallworth, Stallwort, Stallwith
- Staley, Steheley, Stehley
- Stam, Stame, Stum
- Stambach, Stambaugh, Stombaugh, Stumbo
- Stansbury, Stanbery, Stanbury, Stansbery
- Standish, Standishe, Standis
- Standoff, Standoffe, Standofe
- Stanford, Stanfort, Sandford, Sanford
- Stanley, Stanly, Standlely, Standly, Stanely
- Stannard, Stanard, Stanarde
- Stanton, Stantin, Stontan
- Stapler, Stappler, Staplers
- Staples, Staple, Stapples
- Stapleton, Stapleten, Stapletin, Stebleton, Stapledon, Steepleton
- Stapp, Stappe, Sttape, Stape, Sapp, Sap, Stepp, Stap
- Strasser, Streaser, Straser
- Stares, Staires, Starr
- Starkey, Starky, Starkeye
- Steal, Steel, Steall, Stihl, Steele, Steale, Steile, Stiehl
- Steaderman, Staderman, Strotherman, Strowderman
- Stearns, Starnes, Starns, Stern, Sterns
- Steed, Stead, Steede
- Steifel, Steifell, Stiefel
- Steiger, Stieger, Stiegers
- Stein, Stien, Stine
- Sterling, Starling, Stirling
- Stern, Sterns, Stearns, Starn, Starnes
- Stetzel, Stetxel, Stetsel
- Steuben, Stueben, Steubin
- Stevens, Steffens, Stephens, Stephen, Steffy, Steffen
- Stevenson, Stephenson, Stephensen
- Stewart, Stuart, Steuart, Steward
- Stickney, Stickey, Strickney
- Stiegel, Steagall, Stegal, Stegall, Stigal
- Stiely, Stealy, Steely
- Stillman, Stealman, Stillmans
- Stillwagon, Stilwagon, Stillwaggon
- Stifuler, Stiffiller, Stiffuler, Stifler, Stiphiler
- Stiles, Stile, Styles
- Stillings, Stilling, Stilings
- Stinchfield, Stinhfield, Stinckfield, Stimpson, Stimson
- Stirling, Sturling, Stirlings
- Stives, Styves, Stive
- Stockey, Stockly, Stokely
- Stockwell, Stockwel, Stockwill
- Stoddard, Stodder, Stoddert, Stodert
- Stokes, Stoakes, Stockes
- Stockbridge, Stockbrige, Stokbridge
- Stockport, Stockpor, Stockper
- Stockslager, Stockleger, Stocksleger
- Stockstill, Stockstell, Stockstil
- Stockwell, Stockwill, Stockwel
- Stoffel, Stoefell, Stoffell, Stoffels, Stoffle, Stofle, Stophel, Stouffel
- Stoker, Stocker, Stokker
- Stone, Stein, Steine
- Stonebridge, Stonbridge, Stonebrige
- Stoner, Steiner, Stiener
- Stonestreet, Stonestreat, Stonetreet
- Stoodley, Stoodly, Stoodeley
- Story, Storey, Storry
- Stouffer, Stoufer, Stoaffer
- Stoughton, Stoghton, Stoughtons
- Stout, Stoud, Stoudt, Staudt
- Stouther, Stauther, Stowther
- Stover, Stauffer, Stober, Stoever, Stofer, Stauber, Stober, Stoever, Stouffer
- Stow, Stowe, Stough, Steau
- Stoodley, Stoodly, Studley, Study
- Strachan, Strackan, Strachans
- Strack, Strauck, Struck
- Strader, Straud, Strater
- Stradling, Straddling, Strading
- Strait, Stright, Straite
- Strasburg, Strasberg, Strasburgs
- Strasser, Streaser, Straser
- Stratton, Strattan, Strattin
- Straub, Stroup, Straup
- Straw, Stroh, Strow
- Straun, Straune, Strane
- Strayer, Staier, Straer, Stroeher
- Street, Streat, Streett, Stret, Streets
- Stribling, Striplin, Striblin, Stripland
- Strickland, Stricklen, Stricklin
- Stringer, Streinger, Stranger
- Stringfellow, Stringfelder, Stringfelter
- Strode, Straude, Stroude
- Stroope, Stroop, Stroup, Stroupe
- Strong, Stronge, Straung, Strongs
- Stroud, Stroude, Straud, Stode
- Strout, Stout, Staud
- Strowbridge, Strobridge, Strawbridge
- Stucky, Stooky, Stuckey
- Stull, Stoll, Stolle
- Sturgis, Sturges, Sturge
- Strubhar, Strubher, Stubhar
- Strunk, Strank, Straunk
- Struthers, Struther, Strauther
- Stryker, Striker
- Stubbs, Stub, Stubb
- Sturgis, Sturge, Sturges
- Sturtevant, Sturdevant, Sturdivant, Sturtivent
- Stutzman, Stutsman, Stuttzman
- Suarez, Southern Army
- Suber, Subber, Subers
- Sublett, Subblett, Sublet, Soblett, Soblet
- Sugar, Sugar, Suggar
- Suggs, Sugg, Sugges, Sug, Sugge
- Sullard, Sellard, Sellards, Sullards
- Sullivan, Sulivan, Sulivant, Sullivant, Sylivan
- Summerour, Summerow, Sumrow
- Summers, Summer, Sommers, Sommer, Somers
- Summerfield. Sumerfield, Summerfeld
- Sumner, Sumners, Summer
- Sumpter, Sumter, Sumbter
- Supinger, Seepinges, Subinger
- Sutherland, Sunderland, Southerland, Sutherland
- Sutton, Sitton, Suttan
- Supthen, Sutfin, Sutphin
- Swadner, Swadder, Swader
- Swaim, Swim, Swam, Swayne, Schwemm, Swem, Swemme, Sweym
- Swan, Swaun, Swam, Swaum, Suam, Suan, Swane, Swann
- Swanton, Swaunton, Swanten
- Swart, Schwartz, Swarts, Swartz
- Sweeney, Swaney, Sweeny, Swinney, Swinny
- Sweeten, Sweetin, Sweeden, Sweedin, Sweden
- Sweetser, Switzer, Switser
- Swett, Sweat, Sweatt, Sweet
- Swicegood, Swisgood, Swicegoode
- Swift, Swiftt, Sweift
- Swindle, Swindell, Swindal
- Swinehart, Swinhart, Swynhart, Sweinhart, Swihart
- Swisher, Swishner, Switcher
- Swope, Schwoob, Swoope
- Swords, Sword, Sworts
- Swynford, Swinford, Swynfort, Swinfort
- Sykes, Sycks, Sikes, Sicks, Sykis, Six
- Syester, Cyster, Syster, Zeister
- Sylvester, Silvester, Sylvestar
- Syracuse, Siracuse
- Syster, Syester, Cyster, Zeister
